How to Make a Classic Meatloaf Sandwich

Why you’ll love this sandwich

A meatloaf sandwich is one of the best ways to transform leftover meatloaf into a fresh, craveable meal. It lands somewhere between a classic patty melt and a BBQ cheeseburger, combining warm, savory meat with melty cheese and bold condiments for a take-anywhere comfort-food bite.

1. Perfect texture contrast. Juicy meatloaf slices paired with melted cheddar, crisp pickles, crunchy fried onion strings and buttery toasted bread deliver a mix of textures that make every bite exciting.
2. Bold, balanced flavors. The smoky-sweet BBQ sauce combined with mayo creates a creamy, tangy spread that complements the savory meatloaf and sharp cheddar. Pickles add acidity while fried onions bring a satisfying crunch.
3. Fast and simple. Using already-cooked meatloaf speeds assembly: these sandwiches come together in about 15 minutes, making them ideal for quick lunches, easy dinners or a weeknight comfort meal.

Ingredients

Below are the best ingredients for a classic meatloaf sandwich and suggested substitutions. For exact amounts, see the recipe card at the bottom of the page.

• Butter – softened, for toasting the bread.
• Sourdough or hearty bread – thick slices like sourdough, rye or Texas toast work great; choose sturdy bread so it holds up to the fillings.
• Mayonnaise – creates a creamy base in the BBQ mayo spread; if you prefer, increase the BBQ sauce and omit the mayo.
• BBQ sauce – smoky-sweet sauce helps finish the meatloaf flavor and pairs beautifully with cheddar.
• Sharp cheddar cheese – sliced cheddar melts evenly; shredded works in a pinch.
• Dill pickles – sliced pickles add tang and crunch; optional if you don’t like pickles.
• Onions – fried onion strings add crispness; raw or caramelized onions are fine alternatives.
• Cooked meatloaf – works with any style of meatloaf, fresh or leftover (beef, turkey or smoked versions).

Optional toppings: lettuce, tomato, extra BBQ sauce or spicy mustard—customize to taste.

Instructions

These step-by-step directions keep the process quick and straightforward. Photos are shown below to guide you visually.

1. Prepare the bread and sauce. Spread softened butter on one side of each bread slice. In a small bowl, mix equal parts BBQ sauce and mayonnaise (or adjust to taste). Spread the BBQ-mayo mixture on the unbuttered side of each slice.
2. Layer cheese and toppings. Place two overlapping cheddar slices on the BBQ-mayo side of each bread slice. On half of the slices add pickles and fried onion strings (or your preferred onion style).
3. Warm the meatloaf. Heat a large skillet or griddle over medium-high. Warm meatloaf slices 2 minutes per side until heated through. Place a hot meatloaf slice over the pickles and onions.
4. Assemble and cook the sandwich. Top with the remaining bread slices, butter side facing out. Return sandwiches to the skillet and cook 3–4 minutes per side, pressing lightly, until the bread is golden and the cheese is melted. Slice in half and serve immediately.

Tip: These sandwiches are best enjoyed hot. Only prepare as many as you plan to eat right away; you can always make more later.

What to serve with it

Keep sides simple for a casual meal, or choose a hearty pairing. Popular options include:

• French fries – classic or seasoned varieties like truffle or rosemary Parmesan.
• Onion rings or tater tots – crisp, fried sides add extra crunch.
• Pickles or a simple salad – bright, acidic sides cut through the richness of the sandwich.
• Coleslaw or potato salad – creamy, cool salads are a comforting complement.

More sandwich ideas

If you enjoy layered, flavorful sandwiches, try other favorites such as Pastrami Sandwich, Turkey Pesto Sandwich, Reuben, or a Pizza Grilled Cheese.

Meatloaf Sandwich